Glucocorticoid (GC) sensitivity and GC receptor expression differ in thymocyte subpopulations

Glucocorticoid (GC) sensitivity and GC receptor expression differ in thymocyte subpopulations.

Positive and negative selection steps in the thymus prevent non-functional or harmful T cells from reaching the periphery. To examine the role of glucocorticoid (GC) hormone and its intracellular receptor (GCR) in thymocyte development we measured the GCR expression in different thymocyte subpopulations of BALB/c mice with or without previous dexamethasone (DX), anti-CD3 mAb, RU-486 and RU-4304...

GC×GC Handbook Fundamental Principles of Comprehensive 2D GC

Cultured embryonic hippocampal neurons deficient in glucocorticoid (GC) receptor: a novel model for studying nongenomic effects of GC in the neural system.

Glucocorticoid (GC) acts through both genomic and nongenomic mechanisms. It affects the structure and function of the central nervous system, especially the hippocampus. Here we report an in vitro culture system that can yield embryonic hippocampal neurons deficient in the expression of GC receptor as demonstrated by immunoblotting, immunocytochemistry, and RT-PCR. Owing to this unique feature,...

Polymer Analysis Using Pyrolysis-GC-FTIR-MS and GC-AED

Grigg GC

1. Fishes in Antarctic seas live at a temperature lower than that at which most other poikilotherms remain active. 2. Hematocrit, absolute oxygen capacity and oxygen equilibrium curves were determined for whole blood from each of four related species of Antarctic fishes. These parameters were related to the habits and activity of each species. 3. Temperature increase was found to have a marked ...